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Sensors 2006, 6(5), 473-479; doi:10.3390/s6050473

Article

Simulation Study of Nano Aqueous Flow Sensor Based on Amperometric Measurement

Jian Wu ¹ , Qingli Zhou ² , Jun Liu ^1,*  and Zhengguo Lou ¹

¹ Department of Biomedical Engineering, Zhejiang University, 38 ZheDa Road, Hangzhou 310027, PR China ² Women’s Hospital, Zhejiang University, 2 Xueshi Road, Hangzhou 310006, PR China

* Author to whom correspondence should be addressed.

Received: 10 November 2005; in revised form: 13 March 2006 / Accepted: 17 March 2006 / Published: 6 April 2006

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Abstract: In this paper, a novel nano aqueous flow sensor which consists of two closelyspaced amperometric sensors is investigated by digital simulation. The simulation resultsindicate that the ratio of the responses of two closely spaced amperometric sensors is onlyrelated to flow rates in the channel, insensitive to the analyte concentration in the solution.By comparing the output of two amperometric sensors, the flow rate in the channel can bededuced. It is not necessary to determine the analyte concentration in advance. Thesimulation results show it is able to detect flow rate by in the range of several nano-liters perminute when the distance between the working electrodes of two amperometric sensors is200 nm and the cross-section of the channel is 1 μm x 1 μm.

Keywords: flow sensor; amperometric sensor; channel; simulation.

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