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Sensors 2006, 6(10), 1333-1344; doi:10.3390/s6101333

Development of Multichannel Artificial Lipid-Polymer Membrane Sensor for Phytomedicine Application

1
School of Bioprocess Engineering, Northern Malaysia University College of Engineering, 01000 Kangar, Perlis, Malaysia
2
School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
*
Author to whom correspondence should be addressed.
Received: 10 March 2006 / Revised: 6 October 2006 / Accepted: 16 October 2006 / Published: 17 October 2006
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Abstract

Quality control of herbal medicines remain a challenging issue towardsintegrating phytomedicine into the primary health care system. As medicinal plants is acomplicated system of mixtures, a rapid and cost-effective evaluation method tocharacterize the chemical fingerprint of the plant without performing laborious samplepreparation procedure is reported. A novel research methodology based on an in-housefabricated multichannel sensor incorporating an array of artificial lipid-polymer membraneas a fingerprinting device for quality evaluation of a highly sought after herbal medicine inthe Asean Region namely Eurycoma longifolia (Tongkat Ali). The sensor array is based onthe principle of the bioelectronic tongue that mimics the human gustatory system throughthe incorporation of artificial lipid material as sensing element. The eight non-specificsensors have partially overlapping selectivity and cross-sensitivity towards the targetedanalyte. Hence, electrical potential response represented by radar plot is used to characterizeextracts from different parts of plant, age, batch-to-batch variation and mode of extraction ofE. longifolia through the obtained potentiometric fingerprint profile. Classification modelwas also developed classifying various E. longifolia extracts with the aid of chemometricpattern recognition tools namely hierarchical cluster analysis (HCA) and principalcomponent analysis (PCA). The sensor seems to be a promising analytical device for qualitycontrol based on potentiometric fingerprint analysis of phytomedicine. View Full-Text
Keywords: Lipid membrane sensor; Fingerprint profiling; Quality control; Phytomedicine; Eurycoma longifolia; Chemometric. Lipid membrane sensor; Fingerprint profiling; Quality control; Phytomedicine; Eurycoma longifolia; Chemometric.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ahmad, M.N.; Ismail, Z.; Chew, O.; Islam, A.S.; Md Shakaff, A.Y. Development of Multichannel Artificial Lipid-Polymer Membrane Sensor for Phytomedicine Application. Sensors 2006, 6, 1333-1344.

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