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Softlithography in Chemical Sensing – Analytes from Molecules to Cells
Institute for Analytical Chemistry and Food Chemistry, Faculty of Chemistry, Vienna University, Waehringer Strasse 38, A-1090 Vienna, Austria
EPCOS AG, SAW RD IP, Anzingerstrasse 13, D-81617 München, Germany
* Author to whom correspondence should be addressed.
Received: 5 September 2005; Accepted: 28 November 2005 / Published: 1 December 2005
Abstract: Imprinting is a flexible and straightforward technique to generate selective sensormaterials e.g. for mass-sensitive detection. Inherently, the strategy suits both molecularanalytes and entire micro organisms or cells. Imprinted polyurethanes e.g. are capable ofdistinguishing the different xylene isomers with very appreciable selectivity factors.Combining imprinted titanates with surface transverse wave resonators (STW) leads to apowerful tool for detecting engine oil degradation, which is an excellent example foroxidative deterioration processes in a highly complex matrix. Surface imprints withgeometrically equal cavities exhibit clear chemical selectivity, as can e.g. be seen throughthe example of different human rhinovirus (HRV) serotypes. Another example is a bloodgroup-selective sensor prepared by templating with erythrocyte ghosts. Both the bloodgroupA and B imprinted material selectively distinguish between blood groups A, B and O,whereas no difference in sensor signal has been observed for AB, where both blood groupantigen types are present on the cell surface.
Keywords: Imprinting; QCM; SAW; VOCs detection; engine oil degradation; HRV; erythrocytes
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Lieberzeit, P.A.; Glanznig, G.; Jenik, M.; Sylwia Gazda-Miarecka, S.; Dickert, F.L.; Leidl, A. Softlithography in Chemical Sensing – Analytes from Molecules to Cells. Sensors 2005, 5, 509-518.
Lieberzeit PA, Glanznig G, Jenik M, Sylwia Gazda-Miarecka S, Dickert FL, Leidl A. Softlithography in Chemical Sensing – Analytes from Molecules to Cells. Sensors. 2005; 5(12):509-518.
Lieberzeit, Peter A.; Glanznig, Gerd; Jenik, Michael; Sylwia Gazda-Miarecka, Sylwia; Dickert, Franz L.; Leidl, Anton. 2005. "Softlithography in Chemical Sensing – Analytes from Molecules to Cells." Sensors 5, no. 12: 509-518.