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Sensors 2002, 2(10), 424-431; doi:10.3390/s21000424

Ion Selective PVC Membrane Electrode for the Determination of Methacycline Hydrochloride in Pharmaceutical Formulation

Pharmaceutical Analysis Laboratory Biological and Medical Research Department, MBC-03-65, King Faisal Specialist Hospital & Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia
Department of Chemical Engineering, Jiangsu Institute of Petrochemical Technology, Changzhou 213016, Peoples Republic of China
P.O. Box 1048, Beijing 102205, Peoples Republic of China
Author to whom correspondence should be addressed.
Received: 10 May 2002 / Accepted: 15 May 2002 / Published: 18 October 2002
(This article belongs to the Special Issue Ion Sensors)
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A plastic membrane electrode for the determination of methacycline hydrochloride was fabricated based on the use of methacycline-tetraphenylborate as the electroactive substance, and dioctylphtalate as the plasticizing agent. It was found that the potential responses of the electrode were influenced by pH of the tested solution when pH>3. Under the condition of pH 2.6, the linear response range, slope (25ºC) and detection limit obtained were 3.0×10-2~6.0×10-6M, 52.9mv per decade and 3.4×10-6M ,respectively. The response time of the electrodes was <15 seconds. The values of recovery obtained were 99.2~101.2%. The electrode was successfully applied to determination of methacycline hydrochloride in tablet by direct potentiometric method. The result obtained with the electrode was in good agreement with the value obtained by using the official method (highperformance liquid chromatography).
Keywords: Ion-selective electrode; Potentiometry; Methacycline; Drug analysis Ion-selective electrode; Potentiometry; Methacycline; Drug analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Aboul-Enein, H.Y.; Sun, X.X.; Sun, C.J. Ion Selective PVC Membrane Electrode for the Determination of Methacycline Hydrochloride in Pharmaceutical Formulation. Sensors 2002, 2, 424-431.

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