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Sensors 2002, 2(10), 432-435; doi:10.3390/s21000432

Reagents for Lithium Electrodes and Sensors for Blood Serum Analysis

Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA
Received: 17 April 2002 / Accepted: 25 April 2002 / Published: 18 October 2002
(This article belongs to the Special Issue Ion Sensors)
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Abstract

The measurement of lithium in blood serum requires high selectivity since the blood contains about 140 mM sodium compared to the 0.5-1.5 mM lithium level in manic depressive patients under treatment with lithium salts. This review traces the development of optical and potentiometric methods for the selective measurement of lithium in the presence of sodium. Selectivities of over 1,000:1 are achievable with properly designed ionophores.
Keywords: Spectrophotometry; Fluorescence; Sensors; Ion-Selective Electrodes; Crown Ethers; Cryptands; Diamide Ionophores Spectrophotometry; Fluorescence; Sensors; Ion-Selective Electrodes; Crown Ethers; Cryptands; Diamide Ionophores
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Christian, G.D. Reagents for Lithium Electrodes and Sensors for Blood Serum Analysis. Sensors 2002, 2, 432-435.

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