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Sensors 2018, 18(2), 451; https://doi.org/10.3390/s18020451

Polymeric Flexible Immunosensor Based on Piezoresistive Micro-Cantilever with PEDOT/PSS Conductive Layer

†,* and
School of Instrument and Electronics, North University of China, Taiyuan 030051, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 December 2017 / Revised: 26 January 2018 / Accepted: 31 January 2018 / Published: 3 February 2018
(This article belongs to the Special Issue Polymer-Based Sensors for Bioanalytes)
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Abstract

In this paper, a fully polymeric micro-cantilever with the surface passivation layer of parylene-C and the strain resistor of poly(3,4-ethylenedioxythiophene)/poly (styrene sulfonate) (PEDOT/PSS) was proposed and demonstrated for immunoassays. By optimizing the design and fabrication of the polymeric micro-cantilever, a square resistance of 220 Ω/□ for PEDOT/PSS conductive layer have been obtained. The experimental spring constant and the deflection sensitivity were measured to be 0.017 N/m and 8.59 × 10−7 nm−1, respectively. The biological sensing performances of polymeric micro-cantilever were investigated by the immunoassay for human immunoglobulin G (IgG). The immunosensor was experimentally demonstrated to have a linear behavior for the detection of IgG within the concentrations of 10~100 ng/mL with a limit of detection (LOD) of 10 ng/mL. The experimental results indicate that the proposed polymeric flexible conductive layer-based sensors are capable of detecting trace biological substances. View Full-Text
Keywords: flexible micro-cantilever; PEDOT/PSS; polymeric sensor; immunoassay flexible micro-cantilever; PEDOT/PSS; polymeric sensor; immunoassay
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Zhao, R.; Sun, Y. Polymeric Flexible Immunosensor Based on Piezoresistive Micro-Cantilever with PEDOT/PSS Conductive Layer. Sensors 2018, 18, 451.

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