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Sensors 2018, 18(2), 440; https://doi.org/10.3390/s18020440

Improvement in Limit of Detection of Enzymatic Biogas Sensor Utilizing Chromatography Paper for Breath Analysis

Department of Electrical and Electronic Engineering, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan
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Received: 1 December 2017 / Revised: 19 January 2018 / Accepted: 25 January 2018 / Published: 2 February 2018
(This article belongs to the Special Issue I3S 2017 Selected Papers)
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Abstract

Breath analysis is considered to be an effective method for point-of-care diagnosis due to its noninvasiveness, quickness and simplicity. Gas sensors for breath analysis require detection of low-concentration substances. In this paper, we propose that reduction of the background current improves the limit of detection of enzymatic biogas sensors utilizing chromatography paper. After clarifying the cause of the background current, we reduced the background current by improving the fabrication process of the sensors utilizing paper. Finally, we evaluated the limit of detection of the sensor with the sample vapor of ethanol gas. The experiment showed about a 50% reduction of the limit of detection compared to previously-reported sensor. This result presents the possibility of the sensor being applied in diagnosis, such as for diabetes, by further lowering the limit of detection. View Full-Text
Keywords: electrochemical sensor; biosensor utilizing paper; gas sensor; limit of detection electrochemical sensor; biosensor utilizing paper; gas sensor; limit of detection
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Motooka, M.; Uno, S. Improvement in Limit of Detection of Enzymatic Biogas Sensor Utilizing Chromatography Paper for Breath Analysis. Sensors 2018, 18, 440.

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