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Sensors 2018, 18(2), 381; doi:10.3390/s18020381

An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane

1
Department of Mechanical Engineering, K.N. Toosi University of Technology, Tehran 16315-1355, Iran
2
Faculty of Electrical and Computer Engineering, K.N. Toosi University of Technology, Tehran 16315-1355, Iran
3
Departement of Electrical Engineering and Computer Science, York University, Toronto, ON M3J1P3, Canada
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 2 December 2017 / Accepted: 7 December 2017 / Published: 29 January 2018
(This article belongs to the Special Issue Bio-MEMS for Precision Medicine)
View Full-Text   |   Download PDF [6399 KB, uploaded 29 January 2018]   |  

Abstract

One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many various methods for drug delivery systems. Carbon-based nanocarriers are a new efficient tool for translocating drug into the defined area or cells inside the body. These nanocarriers can be functionalized with proteins, peptides and used to transport their freight to cells or defined areas. Since functionalized carbon-based nanocarriers show low toxicity and high biocompatibility, they are used in many nanobiotechnology fields. In this study, different shapes of nanocarrier are investigated, and the suitable magnetic field, which is applied using MRI for the delivery of the nanocarrier, is proposed. In this research, based on the force required to cross the membrane and MD simulations, the optimal magnetic field profile is designed. This optimal magnetic force field is derived from the mathematical model of the system and magnetic particle dynamics inside the nanocarrier. The results of this paper illustrate the effects of the nanocarrier’s shapes on the percentage of success in crossing the membrane and the optimal required magnetic field. View Full-Text
Keywords: magnetic nanocarrier; magnetic field; molecular dynamics simulations; drug delivery; magnetic resonance imaging (MRI) magnetic nanocarrier; magnetic field; molecular dynamics simulations; drug delivery; magnetic resonance imaging (MRI)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mehrafrooz, B.; Pedram, M.Z.; Ghafar-Zadeh, E. An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane. Sensors 2018, 18, 381.

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