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Sensors 2018, 18(1), 263; doi:10.3390/s18010263

Minimally-Invasive Neural Interface for Distributed Wireless Electrocorticogram Recording Systems

1
Apple Incorporated, Cupertino, CA 95014, USA
2
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Received: 5 December 2017 / Revised: 11 January 2018 / Accepted: 12 January 2018 / Published: 17 January 2018
(This article belongs to the Special Issue Implantable Sensors 2017)

Abstract

This paper presents a minimally-invasive neural interface for distributed wireless electrocorticogram (ECoG) recording systems. The proposed interface equips all necessary components for ECoG recording, such as the high performance front-end integrated circuits, a fabricated flexible microelectrode array, and wireless communication inside a miniaturized custom-made platform. The multiple units of the interface systems can be deployed to cover a broad range of the target brain region and transmit signals via a built-in intra-skin communication (ISCOM) module. The core integrated circuit (IC) consists of 16-channel, low-power push-pull double-gated preamplifiers, in-channel successive approximation register analog-to-digital converters (SAR ADC) with a single-clocked bootstrapping switch and a time-delayed control unit, an ISCOM module for wireless data transfer through the skin instead of a power-hungry RF wireless transmitter, and a monolithic voltage/current reference generator to support the aforementioned analog and mixed-signal circuit blocks. The IC was fabricated using 250 nm CMOS processes in an area of 3.2 × 0.9 mm2 and achieved the low-power operation of 2.5 µW per channel. Input-referred noise was measured as 5.62 µVrms for 10 Hz to 10 kHz and ENOB of 7.21 at 31.25 kS/s. The implemented system successfully recorded multi-channel neural activities in vivo from a primate and demonstrated modular expandability using the ISCOM with power consumption of 160 µW. View Full-Text
Keywords: Electrocorticogram (ECoG); low-power; low-noise; neural recording; push-pull double-gated amplifier; intra-skin communication (ISCOM); neural interface Electrocorticogram (ECoG); low-power; low-noise; neural recording; push-pull double-gated amplifier; intra-skin communication (ISCOM); neural interface
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chang, S.-I.; Park, S.-Y.; Yoon, E. Minimally-Invasive Neural Interface for Distributed Wireless Electrocorticogram Recording Systems. Sensors 2018, 18, 263.

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