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Sensors 2018, 18(1), 199; https://doi.org/10.3390/s18010199

Preparation of Cu2O-Reduced Graphene Nanocomposite Modified Electrodes towards Ultrasensitive Dopamine Detection

1
Hunan Key Laboratory of Biomedical Nanomaterials and Devices, School of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, China
2
Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 December 2017 / Revised: 3 January 2018 / Accepted: 10 January 2018 / Published: 12 January 2018
(This article belongs to the Special Issue Graphene Based Sensors and Electronics)
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Abstract

Cu2O-reduced graphene oxide nanocomposite (Cu2O-RGO) was used to modify glassy carbon electrodes (GCE), and applied for the determination of dopamine (DA). The microstructure of Cu2O-RGO nanocomposite material was characterized by scanning electron microscope. Then the electrochemical reduction condition for preparing Cu2O-RGO/GCE and experimental conditions for determining DA were further optimized. The electrochemical behaviors of DA on the bare electrode, RGO- and Cu2O-RGO-modified electrodes were also investigated using cyclic voltammetry in phosphate-buffered saline solution (PBS, pH 3.5). The results show that the oxidation peaks of ascorbic acid (AA), dopamine (DA), and uric acid (UA) could be well separated and the peak-to-peak separations are 204 mV (AA-DA) and 144 mV (DA-UA), respectively. Moreover, the linear response ranges for the determination of 1 × 10−8 mol/L~1 × 10−6 mol/L and 1 × 10−6 mol/L~8 × 10−5 mol/L with the detection limit 6.0 × 10−9 mol/L (S/N = 3). The proposed Cu2O-RGO/GCE was further applied to the determination of DA in dopamine hydrochloride injections with satisfactory results. View Full-Text
Keywords: Cu2O nanoparticles; reduced graphene oxide; modified electrode; dopamine detection; electrochemical oxidation Cu2O nanoparticles; reduced graphene oxide; modified electrode; dopamine detection; electrochemical oxidation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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He, Q.; Liu, J.; Liu, X.; Li, G.; Deng, P.; Liang, J. Preparation of Cu2O-Reduced Graphene Nanocomposite Modified Electrodes towards Ultrasensitive Dopamine Detection. Sensors 2018, 18, 199.

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