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Sensors 2018, 18(1), 15; doi:10.3390/s18010015

Fast and Sensitive Ellipsometry-Based Biosensing

1,2,†
,
2,†
,
1
,
2
,
1,2
,
2
and
1,2,*
1
School of Information and Communication Engineering, North University of China, Taiyuan 030051, China
2
Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 11 October 2017 / Revised: 13 December 2017 / Accepted: 20 December 2017 / Published: 22 December 2017
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [3879 KB, uploaded 22 December 2017]   |  

Abstract

In this work, a biosensing method based on in situ, fast, and sensitive measurements of ellipsometric parameters (Ψ, ∆) is proposed. Bare silicon wafer substrate is functionalized and used to bind biomolecules in the solution. Coupled with a 45° dual-drive symmetric photoelastic modulator-based ellipsometry, the parameters Ψ and ∆ of biolayer arising due to biomolecular interactions are determined directly, and the refractive index (RI) of the solution and the effective thickness and surface mass density of the biolayer for various interaction time can be further monitored simultaneously. To illustrate the performance of the biosensing method, immunosensing for immunoglobulin G (IgG) was taken as a case study. The experiment results show that the biosensor response of the limit of detection for IgG is 15 ng/mL, and the data collection time is in milliseconds. Moreover, the method demonstrates a good specificity. Such technique is a promising candidate in developing a novel sensor which can realize fast and sensitive, label-free, easy operation, and cost-effective biosensing. View Full-Text
Keywords: biosensing; ellipsometry; photoelastic modulator; biolayer; refractive index; effective thickness biosensing; ellipsometry; photoelastic modulator; biolayer; refractive index; effective thickness
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MDPI and ACS Style

Li, K.; Wang, S.; Wang, L.; Yu, H.; Jing, N.; Xue, R.; Wang, Z. Fast and Sensitive Ellipsometry-Based Biosensing. Sensors 2018, 18, 15.

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