Next Article in Journal
A Novel Detection Method for Underwater Moving Targets by Measuring Their ELF Emissions with Inductive Sensors
Previous Article in Journal
Load Identification for a Cantilever Beam Based on Fiber Bragg Grating Sensors
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Sensors 2017, 17(8), 1737; doi:10.3390/s17081737

Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications

1
Department of Electronics and Electromagnetism, Faculty of Physics, University of Seville, Av. Reina Mercedes sn, Seville 41012, Spain
2
Group of Microelectronics Engineering, Department of Electronics Technology, Systems Engineering and Automation, University of Cantabria, Santander 39005, Spain
3
Seville Institute of Microelectronics, Microelectronics National Center, Consejo Superior de Investigaciones Científicas (IMSE-CNM-CSIC), Av. Americo Vespuccio, sn, Seville 41092, Spain
4
Computer Engineering School (ETSII), University of Seville, Av. Reina Mercedes sn, Seville 41012, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Nicole Jaffrezic-Renault
Received: 19 May 2017 / Revised: 17 July 2017 / Accepted: 25 July 2017 / Published: 28 July 2017
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [4857 KB, uploaded 28 July 2017]   |  

Abstract

To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT) circuit technique. A mathematical model was developed to analytically describe the histological composition of the neointima, employing its conductivity and permittivity data. The bioimpedance model was validated against a finite element analysis (FEA) using COMSOL Multiphysics software. A satisfactory correlation between the analytical model and FEA simulation was achieved in most cases, detecting some deviations introduced by the thin “double layer” that separates the neointima and the blood. It is hereby shown how to apply conformal transformations to obtain bioimpedance electrical models for stack-layered tissues over coplanar electrodes. Particularly, this can be applied to characterize the neointima in real-time. This technique is either suitable as a main mechanism for restenosis follow-up or it can be combined with proposed intelligent stents for blood pressure measurements to auto-calibrate the sensibility loss caused by the adherence of the tissue on the micro-electro-mechanical sensors (MEMSs). View Full-Text
Keywords: bioimpedance; atherosclerosis; cardiology; oscillation-based test; stent bioimpedance; atherosclerosis; cardiology; oscillation-based test; stent
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Rivas-Marchena, D.; Olmo, A.; Miguel, J.A.; Martínez, M.; Huertas, G.; Yúfera, A. Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications. Sensors 2017, 17, 1737.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top