Next Article in Journal
Microfluidic Platform for the Long-Term On-Chip Cultivation of Mammalian Cells for Lab-On-A-Chip Applications
Next Article in Special Issue
Identification and Quantification of Celery Allergens Using Fiber Optic Surface Plasmon Resonance PCR
Previous Article in Journal
Energy Harvesting Based Body Area Networks for Smart Health
Previous Article in Special Issue
Slab Waveguide and Optical Fibers for Novel Plasmonic Sensor Configurations
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Sensors 2017, 17(7), 1601; doi:10.3390/s17071601

Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate

1,2,†
,
1,†
,
1
,
1,* and 2,*
1
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
2
Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South Central University for Nationalities, Wuhan 430074, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 21 May 2017 / Revised: 17 June 2017 / Accepted: 20 June 2017 / Published: 10 July 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
View Full-Text   |   Download PDF [3506 KB, uploaded 10 July 2017]   |  

Abstract

Sibutramine hydrochloride (SH) is a banned weight-loss drug, but its illegal addition to health products is still rampant. This suggests a very urgent need for a fast and precise detection method for SH. Surface Enhanced Raman Scattering (SERS) is a promising candidate for this purpose, but the weak affinity between SH and bare metal limits its direct SERS detection. In the present work, β-cyclodextrin was capped in situ onto the surface of Ag nanoparticles to function as a scaffold to capture SH. The obtained Ag nanoparticles were encapsulated into polyvinyl alcohol (PVA) to fabricate a SERS active hydrogel with excellent reproducibility. A facile SERS strategy based on such substrate was proposed for trace SH quantification with a linear range of 7.0–150.0 µg·mL–1, and a detection limit low to 3.0 µg·mL−1. It was applied to analyze seven types of commercial slimming capsules with satisfactory results, showing good prospect for real applications. View Full-Text
Keywords: sibutramine hydrochloride; Surface Enhanced Raman Scattering; β-cyclodextrin; polyvinyl alcohol sibutramine hydrochloride; Surface Enhanced Raman Scattering; β-cyclodextrin; polyvinyl alcohol
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ouyang, L.; Jiang, Z.; Wang, N.; Zhu, L.; Tang, H. Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate. Sensors 2017, 17, 1601.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top