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Sensors 2017, 17(7), 1471; doi:10.3390/s17071471

Analysis of Serotonin Molecules on Silver Nanocolloids—A Raman Computational and Experimental Study

1
Department of Physics, University of Texas at El Paso, El Paso, TX 79968, USA
2
Department of Biomedical Engineering, University of Texas at El Paso, El Paso, TX 79968, USA
3
Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USA
4
Division of Engineering, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Received: 24 May 2017 / Revised: 16 June 2017 / Accepted: 20 June 2017 / Published: 22 June 2017
(This article belongs to the Special Issue Applications of Raman Spectroscopy in Biosensors)
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Abstract

Combined theoretical and experimental analysis of serotonin by quantum chemical density functional calculations and surface-enhanced Raman spectroscopy, respectively, is presented in this work to better understand phenomena related to this neurotransmitter’s detection and monitoring at very low concentrations specific to physiological levels. In addition to the successful ultrasensitive analyte detection on silver nanoparticles for concentrations as low as 10−11 molar, the relatively good agreement between the simulated and experimentally determined results indicates the presence of all serotonin molecular forms, such as neutral, ionic, and those oxidized through redox reactions. Obvious structural molecular deformations such as bending of lateral amino chains are observed for both ionic and oxidized forms. Not only does this combined approach reveal more probable adsorption of serotonin into the silver surface through hydroxyl/oxygen sites than through NH/nitrogen sites, but also that it does so predominantly in its neutral (reduced) form, somewhat less so in its ionic forms, and much less in its oxidized forms. If the development of opto-voltammetric biosensors and their effective implementation is envisioned for the future, this study provides some needed scientific background for comprehending changes in the vibrational signatures of this important neurotransmitter. View Full-Text
Keywords: surface-enhanced Raman spectroscopy; theoretical calculations; serotonin detection; silver nanocolloids; biomaterials surface-enhanced Raman spectroscopy; theoretical calculations; serotonin detection; silver nanocolloids; biomaterials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Manciu, F.S.; Ciubuc, J.D.; Sundin, E.M.; Qiu, C.; Bennet, K.E. Analysis of Serotonin Molecules on Silver Nanocolloids—A Raman Computational and Experimental Study. Sensors 2017, 17, 1471.

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