Diagnosis of Breast Cancer Tissues Using 785 nm Miniature Raman Spectrometer and Pattern Regression
AbstractFor achieving the development of a portable, low-cost and in vivo cancer diagnosis instrument, a laser 785 nm miniature Raman spectrometer was used to acquire the Raman spectra for breast cancer detection in this paper. However, because of the low spectral signal-to-noise ratio, it is difficult to achieve high discrimination accuracy by using the miniature Raman spectrometer. Therefore, a pattern recognition method of the adaptive net analyte signal (NAS) weight k-local hyperplane (ANWKH) is proposed to increase the classification accuracy. ANWKH is an extension and improvement of K-local hyperplane distance nearest-neighbor (HKNN), and combines the advantages of the adaptive weight k-local hyperplane (AWKH) and the net analyte signal (NAS). In this algorithm, NAS was first used to eliminate the influence caused by other non-target factors. Then, the distance between the test set samples and hyperplane was calculated with consideration of the feature weights. The HKNN only works well for small values of the nearest-neighbor. However, the accuracy decreases with increasing values of the nearest-neighbor. The method presented in this paper can resolve the basic shortcoming by using the feature weights. The original spectra are projected into the vertical subspace without the objective factors. NAS was employed to obtain the spectra without irrelevant information. NAS can improve the classification accuracy, sensitivity, and specificity of breast cancer early diagnosis. Experimental results of Raman spectra detection in vitro of breast tissues showed that the proposed algorithm can obtain high classification accuracy, sensitivity, and specificity. This paper demonstrates that the ANWKH algorithm is feasible for early clinical diagnosis of breast cancer in the future. View Full-Text
Share & Cite This Article
Li, Q.; Hao, C.; Xu, Z. Diagnosis of Breast Cancer Tissues Using 785 nm Miniature Raman Spectrometer and Pattern Regression. Sensors 2017, 17, 627.
Li Q, Hao C, Xu Z. Diagnosis of Breast Cancer Tissues Using 785 nm Miniature Raman Spectrometer and Pattern Regression. Sensors. 2017; 17(3):627.Chicago/Turabian Style
Li, Qingbo; Hao, Can; Xu, Zhi. 2017. "Diagnosis of Breast Cancer Tissues Using 785 nm Miniature Raman Spectrometer and Pattern Regression." Sensors 17, no. 3: 627.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.