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Sensors 2017, 17(5), 1164; doi:10.3390/s17051164

Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System

1
Industrial and Management Systems Engineering, West Virginia University, Morgantown, WV 26506, USA
2
Montgomery-Downs Lab, Blanchette Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA
3
Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV 26506, USA
4
Department of Radiology, Center for Advanced Imaging, West Virginia University, Morgantown, WV 26506, USA
5
Department of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA
6
Physiology & Pharmacology & Blanchette Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Stefan Bosse, Ansgar Trächtler, Klaus-Dieter Thoben, Berend Denkena and Dirk Lehmhus
Received: 1 February 2017 / Revised: 14 April 2017 / Accepted: 12 May 2017 / Published: 19 May 2017
(This article belongs to the Special Issue System-Integrated Intelligence and Intelligent Systems)
View Full-Text   |   Download PDF [4008 KB, uploaded 23 May 2017]   |  

Abstract

Several applications exist for a whole brain positron-emission tomography (PET) brain imager designed as a portable unit that can be worn on a patient’s head. Enabled by improvements in detector technology, a lightweight, high performance device would allow PET brain imaging in different environments and during behavioral tasks. Such a wearable system that allows the subjects to move their heads and walk—the Ambulatory Microdose PET (AM-PET)—is currently under development. This imager will be helpful for testing subjects performing selected activities such as gestures, virtual reality activities and walking. The need for this type of lightweight mobile device has led to the construction of a proof of concept portable head-worn unit that uses twelve silicon photomultiplier (SiPM) PET module sensors built into a small ring which fits around the head. This paper is focused on the engineering design of mechanical support aspects of the AM-PET project, both of the current device as well as of the coming next-generation devices. The goal of this work is to optimize design of the scanner and its mechanics to improve comfort for the subject by reducing the effect of weight, and to enable diversification of its applications amongst different research activities. View Full-Text
Keywords: positron emission tomography; brain; brain disorders; wearable; microdose; brain injuries; stroke; dementias; autism positron emission tomography; brain; brain disorders; wearable; microdose; brain injuries; stroke; dementias; autism
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MDPI and ACS Style

Melroy, S.; Bauer, C.; McHugh, M.; Carden, G.; Stolin, A.; Majewski, S.; Brefczynski-Lewis, J.; Wuest, T. Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System. Sensors 2017, 17, 1164.

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