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Sensors 2017, 17(4), 819; doi:10.3390/s17040819

Comparison between a Direct-Flow SPR Immunosensor for Ampicillin and a Competitive Conventional Amperometric Device: Analytical Features and Possible Applications to Real Samples

1
Department of Chemistry, “Sapienza” University of Rome, P.le A. Moro, 5, 00185 Rome, Italy
2
Department of Chemistry and Pharmacy Technology, “Sapienza” University of Rome, P.le A. Moro, 5, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 8 February 2017 / Revised: 4 April 2017 / Accepted: 5 April 2017 / Published: 10 April 2017
(This article belongs to the Special Issue Electrochemical Immunosensors)
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Abstract

In this research, we developed a direct-flow surface plasmon resonance (SPR) immunosensor for ampicillin to perform direct, simple, and fast measurements of this important antibiotic. In order to better evaluate the performance, it was compared with a conventional amperometric immunosensor, working with a competitive format with the aim of finding out experimental real advantages and disadvantages of two respective methods. Results showed that certain analytical features of the new SPR immunodevice, such as the lower limit of detection (LOD) value and the width of the linear range, are poorer than those of a conventional amperometric immunosensor, which adversely affects the application to samples such as natural waters. On the other hand, the SPR immunosensor was more selective to ampicillin, and measurements were more easily and quickly attained compared to those performed with the conventional competitive immunosensor. View Full-Text
Keywords: ampicillin; flow surface plasmon resonance (SPR) immunosensor; competitive amperometric immunosensor; analytical comparison ampicillin; flow surface plasmon resonance (SPR) immunosensor; competitive amperometric immunosensor; analytical comparison
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MDPI and ACS Style

Tomassetti, M.; Merola, G.; Martini, E.; Campanella, L.; Sanzò, G.; Favero, G.; Mazzei, F. Comparison between a Direct-Flow SPR Immunosensor for Ampicillin and a Competitive Conventional Amperometric Device: Analytical Features and Possible Applications to Real Samples. Sensors 2017, 17, 819.

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