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Sensors 2017, 17(4), 791; doi:10.3390/s17040791

In Vivo Bioimpedance Spectroscopy Characterization of Healthy, Hemorrhagic and Ischemic Rabbit Brain within 10 Hz–1 MHz

1
Department of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032, China
2
Department of Neurosurgery, Xijing hospital, Fourth Military Medical University, Xi’an 710032, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Nicole Jaffrezic-Renault
Received: 24 January 2017 / Revised: 30 March 2017 / Accepted: 4 April 2017 / Published: 7 April 2017
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [4587 KB, uploaded 7 April 2017]   |  

Abstract

Acute stroke is a serious cerebrovascular disease and has been the second leading cause of death worldwide. Conventional diagnostic modalities for stroke, such as CT and MRI, may not be available in emergency settings. Hence, it is imperative to develop a portable tool to diagnose stroke in a timely manner. Since there are differences in impedance spectra between normal, hemorrhagic and ischemic brain tissues, multi-frequency electrical impedance tomography (MFEIT) shows great promise in detecting stroke. Measuring the impedance spectra of healthy, hemorrhagic and ischemic brain in vivo is crucial to the success of MFEIT. To our knowledge, no research has established hemorrhagic and ischemic brain models in the same animal and comprehensively measured the in vivo impedance spectra of healthy, hemorrhagic and ischemic brain within 10 Hz–1 MHz. In this study, the intracerebral hemorrhage and ischemic models were established in rabbits, and then the impedance spectra of healthy, hemorrhagic and ischemic brain were measured in vivo and compared. The results demonstrated that the impedance spectra differed significantly between healthy and stroke-affected brain (i.e., hemorrhagic or ischemic brain). Moreover, the rate of change in brain impedance following hemorrhagic and ischemic stroke with regard to frequency was distinct. These findings further validate the feasibility of using MFEIT to detect stroke and differentiate stroke types, and provide data supporting for future research. View Full-Text
Keywords: brain impedance spectra; rabbits; stroke brain impedance spectra; rabbits; stroke
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Yang, L.; Liu, W.; Chen, R.; Zhang, G.; Li, W.; Fu, F.; Dong, X. In Vivo Bioimpedance Spectroscopy Characterization of Healthy, Hemorrhagic and Ischemic Rabbit Brain within 10 Hz–1 MHz. Sensors 2017, 17, 791.

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