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Sensors 2017, 17(3), 537; doi:10.3390/s17030537

Twenty-Four-Hour Real-Time Continuous Monitoring of Cerebral Edema in Rabbits Based on a Noninvasive and Noncontact System of Magnetic Induction

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1
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1,3,* , 1
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1,* and 3
1
College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China
2
College of Bioengineering, Chongqing University, Chongqing 400030, China
3
Department of Neurosurgery, Southwest Hospital, Chongqing 400038, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Sandeep Kumar Vashist
Received: 11 January 2017 / Revised: 24 February 2017 / Accepted: 6 March 2017 / Published: 8 March 2017
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [2231 KB, uploaded 8 March 2017]   |  

Abstract

Cerebral edema is a common disease, secondary to craniocerebral injury, and real-time continuous monitoring of cerebral edema is crucial for treating patients after traumatic brain injury. This work established a noninvasive and noncontact system by monitoring the magnetic induction phase shift (MIPS) which is associated with brain tissue conductivity. Sixteen rabbits (experimental group n = 10, control group, n = 6) were used to perform a 24 h MIPS and intracranial pressure (ICP) simultaneously monitored experimental study. For the experimental group, after the establishment of epidural freeze-induced cerebral edema models, the MIPS presented a downward trend within 24 h, with a change magnitude of −13.1121 ± 2.3953°; the ICP presented an upward trend within 24 h, with a change magnitude of 12–41 mmHg. The ICP was negatively correlated with the MIPS. In the control group, the MIPS change amplitude was −0.87795 ± 1.5146 without obvious changes; the ICP fluctuated only slightly at the initial value of 12 mmHg. MIPS had a more sensitive performance than ICP in the early stage of cerebral edema. These results showed that this system is basically capable of monitoring gradual increases in the cerebral edema solution volume. To some extent, the MIPS has the potential to reflect the ICP changes. View Full-Text
Keywords: cerebral edema; noncontact; magnetic induction; intracranial pressure; real-time monitoring cerebral edema; noncontact; magnetic induction; intracranial pressure; real-time monitoring
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, G.; Ma, K.; Sun, J.; Jin, G.; Qin, M.; Feng, H. Twenty-Four-Hour Real-Time Continuous Monitoring of Cerebral Edema in Rabbits Based on a Noninvasive and Noncontact System of Magnetic Induction. Sensors 2017, 17, 537.

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