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Sensors 2017, 17(2), 357; doi:10.3390/s17020357

Performance Characterization of a Switchable Acoustic Resolution and Optical Resolution Photoacoustic Microscopy System

School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
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Academic Editors: Dragan Indjin, Željka Cvejić and Małgorzata Jędrzejewska-Szczerska
Received: 4 January 2017 / Revised: 27 January 2017 / Accepted: 9 February 2017 / Published: 12 February 2017
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Abstract

Photoacoustic microscopy (PAM) is a scalable bioimaging modality; one can choose low acoustic resolution with deep penetration depth or high optical resolution with shallow imaging depth. High spatial resolution and deep penetration depth is rather difficult to achieve using a single system. Here we report a switchable acoustic resolution and optical resolution photoacoustic microscopy (AR-OR-PAM) system in a single imaging system capable of both high resolution and low resolution on the same sample. Lateral resolution of 4.2 µm (with ~1.4 mm imaging depth) and lateral resolution of 45 μm (with ~7.6 mm imaging depth) was successfully demonstrated using a switchable system. In vivo blood vasculature imaging was also performed for its biological application. View Full-Text
Keywords: photoacoustic imaging; AR-PAM; OR-PAM; microscopy; deep tissue imaging photoacoustic imaging; AR-PAM; OR-PAM; microscopy; deep tissue imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moothanchery, M.; Pramanik, M. Performance Characterization of a Switchable Acoustic Resolution and Optical Resolution Photoacoustic Microscopy System. Sensors 2017, 17, 357.

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