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Sensors 2017, 17(12), 2819; https://doi.org/10.3390/s17122819

Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects

State Key Laboratory of Precision Measurement Technology and Instruments, Tsinghua University, Beijing 100084, China
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Received: 20 October 2017 / Revised: 27 November 2017 / Accepted: 29 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
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Abstract

Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, several methods have been developed for SPR phase interrogation, including heterodyne detection, polarimetry, shear interferometry, spatial phase modulation interferometry and temporal phase modulation interferometry. This paper summarizes the fundamentals of phase-sensitive SPR sensing, reviews the available methods for phase interrogation of these sensors, and discusses the future prospects for and trends in the development of this technology. View Full-Text
Keywords: surface plasmon resonance; phase detection; heterodyne; ellipsometry; interferometry surface plasmon resonance; phase detection; heterodyne; ellipsometry; interferometry
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Deng, S.; Wang, P.; Yu, X. Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects. Sensors 2017, 17, 2819.

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