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Sensors 2017, 17(11), 2629; https://doi.org/10.3390/s17112629

Biosensors to Diagnose Chagas Disease: A Brief Review

1
Departamento de Ciencias Computacionales, Universidad de Quintana Roo, Unidad Cancún, 77519 Cancún, Mexico
2
Escuela de Ciencias de la Ingeniería y Tecnología, Cuerpo Académico de Bioingeniería y Salud Ambiental, Universidad Autónoma de Baja California, 22260 Tijuana, Mexico
3
Institut Jean Lamour, 54600 Villers-lès-Nancy, France
4
Departamento de Ecología Humana, Cinvestav Unidad Mérida, 97310 Mérida, Mexico
*
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 9 November 2017 / Accepted: 11 November 2017 / Published: 15 November 2017
(This article belongs to the Special Issue Sensors for Health Monitoring and Disease Diagnosis)
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Abstract

Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America’s main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T. cruzi load measurements in settings where CD is most prevalent are needed to enable enhanced intervention strategies. This work analyzes the potential contribution of biosensing technologies, reviewing examples that have been tested and contrasted with traditional methods, both serological and parasitological (i.e., molecular detection by PCR), and discusses some emerging biosensing technologies that have been applied for this public health issue. Even if biosensing technologies still require further research efforts to develop portable systems, we arrive at the conclusion that biosensors could improve the accuracy of CD diagnosis and the follow-up of patients’ treatments in terms of the rapidity of results, small sample volume, high integration, ease of use, real-time and low cost detection when compared with current conventional technologies. View Full-Text
Keywords: Chagas disease; biosensors; detection technologies; diagnosis Chagas disease; biosensors; detection technologies; diagnosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Rocha-Gaso, M.-I.; Villarreal-Gómez, L.-J.; Beyssen, D.; Sarry, F.; Reyna, M.-A.; Ibarra-Cerdeña, C.-N. Biosensors to Diagnose Chagas Disease: A Brief Review. Sensors 2017, 17, 2629.

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