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Sensors 2017, 17(11), 2559; doi:10.3390/s17112559

Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating

1
College of Physics and Electronic Engineering, Shanxi University, Taiyuan 030006, China
2
Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China
3
School of Information and Communication Engineering, North University of China, Taiyuan 030051, China
*
Author to whom correspondence should be addressed.
Received: 13 September 2017 / Revised: 2 November 2017 / Accepted: 3 November 2017 / Published: 6 November 2017
(This article belongs to the Special Issue Label-Free Biosensors)
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Abstract

A compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refractive index (RI). In addition, being insensitive to the RI variation, the FBG can be applied as a temperature thermometer due to its independent response to the temperature. Surface functionalization to the sensor is carried out to achieve specific targeting of the unlabeled biomarkers. The result shows that the proposed sensor presents a low limit-of-detection (LOD) of 2 ng/mL, enabling its potentials of application in early diagnosis on the breast cancer. View Full-Text
Keywords: fiber taper interferometer; FBG; optical biosensor; cancer biomarker fiber taper interferometer; FBG; optical biosensor; cancer biomarker
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sun, D.; Ran, Y.; Wang, G. Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating. Sensors 2017, 17, 2559.

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