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Sensors 2017, 17(11), 2533; https://doi.org/10.3390/s17112533

Molecular Biosensors for Electrochemical Detection of Infectious Pathogens in Liquid Biopsies: Current Trends and Challenges

Departamento de Química Analítica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain
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Received: 23 September 2017 / Revised: 18 October 2017 / Accepted: 1 November 2017 / Published: 3 November 2017
(This article belongs to the Special Issue Sensors for Toxic and Pathogen Detection)
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Abstract

Rapid and reliable diagnosis of infectious diseases caused by pathogens, and timely initiation of appropriate treatment are critical determinants to promote optimal clinical outcomes and general public health. Conventional in vitro diagnostics for infectious diseases are time-consuming and require centralized laboratories, experienced personnel and bulky equipment. Recent advances in electrochemical affinity biosensors have demonstrated to surpass conventional standards in regards to time, simplicity, accuracy and cost in this field. The tremendous potential offered by electrochemical affinity biosensors to detect on-site infectious pathogens at clinically relevant levels in scarcely treated body fluids is clearly stated in this review. The development and application of selected examples using different specific receptors, assay formats and electrochemical approaches focusing on the determination of specific circulating biomarkers of different molecular (genetic, regulatory and functional) levels associated with bacterial and viral pathogens are critically discussed. Existing challenges still to be addressed and future directions in this rapidly advancing and highly interesting field are also briefly pointed out. View Full-Text
Keywords: electrochemical affinity biosensors; bacteria; viruses; immunosensors; nucleic acid-based sensors; liquid biopsies electrochemical affinity biosensors; bacteria; viruses; immunosensors; nucleic acid-based sensors; liquid biopsies
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Campuzano, S.; Yáñez-Sedeño, P.; Pingarrón, J.M. Molecular Biosensors for Electrochemical Detection of Infectious Pathogens in Liquid Biopsies: Current Trends and Challenges. Sensors 2017, 17, 2533.

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