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Sensors 2017, 17(11), 2452; https://doi.org/10.3390/s17112452

Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films

1
National Enterprise for nanoScience and nanoTechnology (NEST), Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy
2
Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy
Present Address: Menarini Silicon Biosystems SpA, Via di Vittorio 21/B3, 40013 Castel Maggiore (BO), Italy.
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 20 October 2017 / Accepted: 24 October 2017 / Published: 26 October 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
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Abstract

Surface chemical and biochemical functionalization is a fundamental process that is widely applied in many fields to add new functions, features, or capabilities to a material’s surface. Here, we demonstrate that surface acoustic waves (SAWs) can enhance the chemical functionalization of gold films. This is shown by using an integrated biochip composed by a microfluidic channel coupled to a surface plasmon resonance (SPR) readout system and by monitoring the adhesion of biotin-thiol on the gold SPR areas in different conditions. In the case of SAW-induced streaming, the functionalization efficiency is improved 5 times with respect to the case without SAWs. The technology here proposed can be easily applied to a wide variety of biological systems (e.g., proteins, nucleic acids) and devices (e.g., sensors, devices for cell cultures). View Full-Text
Keywords: functionalization; microfluidics; surface acoustic waves (SAWs) functionalization; microfluidics; surface acoustic waves (SAWs)
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Greco, G.; Agostini, M.; Shilton, R.; Travagliati, M.; Signore, G.; Cecchini, M. Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films. Sensors 2017, 17, 2452.

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