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Sensors 2016, 16(9), 1543; doi:10.3390/s16091543

Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study

1
Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore
2
Department of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Fan-Gang Tseng
Received: 29 July 2016 / Revised: 6 September 2016 / Accepted: 13 September 2016 / Published: 21 September 2016
(This article belongs to the Special Issue Biomicrofluidics)
View Full-Text   |   Download PDF [2036 KB, uploaded 21 September 2016]   |  

Abstract

In this study, a biomimetic microfluidic plasma separation device is discussed. The design of the device drew inspiration from in vivo observations of enhanced cell-free layer (CFL) formation downstream of vascular bifurcations. The working principle for the plasma separation was based on the plasma skimming effect in an arteriolar bifurcation, which is modulated by CFL formation. The enhancement of the CFL width was achieved by a local hematocrit reduction near the collection channel by creating an uneven hematocrit distribution at the bifurcation of the channel. The device demonstrated a high purity of separation (~99.9%) at physiological levels of hematocrit (~40%). View Full-Text
Keywords: microfluidics; cell-free layer; hydrodynamic separation; hemodynamics microfluidics; cell-free layer; hydrodynamic separation; hemodynamics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Namgung, B.; Tan, J.K.S.; Wong, P.A.; Park, S.-Y.; Leo, H.L.; Kim, S. Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study. Sensors 2016, 16, 1543.

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