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Sensors 2016, 16(9), 1442; doi:10.3390/s16091442

Dispersion Curve Engineering of TiO2/Silver Hybrid Substrates for Enhanced Surface Plasmon Resonance Detection

1
Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Korea
2
Department of Computer Science and Engineering, Kyung Hee University, Yongin 17104, Korea
3
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Aydogan Ozcan
Received: 27 July 2016 / Revised: 31 August 2016 / Accepted: 2 September 2016 / Published: 7 September 2016
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [3782 KB, uploaded 7 September 2016]   |  

Abstract

As surface plasmon resonance (SPR)-based biosensors are well translated into biological, chemical, environmental, and clinical fields, it is critical to further realize stable and sustainable systems, avoiding oxidation susceptibility of metal films—in particular, silver substrates. We report an enhanced SPR detection performance by incorporating a TiO2 layer on top of a thin silver film. A uniform TiO2 film fabricated by electron beam evaporation at room temperature is an effective alternative in bypassing oxidation of a silver film. Based on our finding that the sensor sensitivity is strongly correlated with the slope of dispersion curves, SPR sensing results obtained by parylene film deposition shows that TiO2/silver hybrid substrates provide notable sensitivity improvement compared to a conventional bare silver film, which confirms the possibility of engineering the dispersion characteristic according to the incidence wavelength. The reported SPR structures with TiO2 films enhance the sensitivity significantly in water and air environments and its overall qualitative trend in sensitivity improvement is consistent with numerical simulations. Thus, we expect that our approach can extend the applicability of TiO2-mediated SPR biosensors to highly sensitive detection for biomolecular binding events of low concentrations, while serving a practical and reliable biosensing platform. View Full-Text
Keywords: surface plasmon resonance biosensor; dispersion engineering; sensitivity; stability surface plasmon resonance biosensor; dispersion engineering; sensitivity; stability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

El-Gohary, S.H.; Choi, M.; Kim, Y.L.; Byun, K.M. Dispersion Curve Engineering of TiO2/Silver Hybrid Substrates for Enhanced Surface Plasmon Resonance Detection. Sensors 2016, 16, 1442.

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