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Sensors 2016, 16(9), 1353; doi:10.3390/s16091353

Influence of Experimental Conditions on Electronic Tongue Results—Case of Valsartan Minitablets Dissolution

1
Department of Microbioanalytics, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland
2
Department of Applied Pharmacy, Gdańsk Medical University, Al. Gen. J. Hallera 107, Gdansk 80-416, Poland
*
Authors to whom correspondence should be addressed.
Academic Editors: Takeshi Onodera and Kiyoshi Toko
Received: 13 June 2016 / Revised: 13 July 2016 / Accepted: 27 July 2016 / Published: 23 August 2016
(This article belongs to the Special Issue Olfactory and Gustatory Sensors)
View Full-Text   |   Download PDF [1273 KB, uploaded 23 August 2016]   |  

Abstract

A potentiometric electronic tongue was applied to study the release of valsartan from pharmaceutical formulations, i.e., minitablets uncoated and coated with Eudragit E. Special attention was paid to evaluate the influence of medium temperature and composition, as well as to compare the performances of the sensor arrays working in various hydrodynamic conditions. The drug dissolution profiles registered with the ion-sensitive electrodes were compared with standard dissolution tests performed with USP Apparatus 2 (paddle). Moreover, the signal changes of all sensors were processed by principal component analysis to visualize the release modifications, related to the presence of the coating agent. Finally, the importance and influence of the experimental conditions on the results obtained using potentiometric sensor arrays were discussed. View Full-Text
Keywords: electronic tongue; potentiometric sensors; drug release; dissolution test; minitablets; valsartan; taste-masking electronic tongue; potentiometric sensors; drug release; dissolution test; minitablets; valsartan; taste-masking
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MDPI and ACS Style

Wesoły, M.; Kluk, A.; Sznitowska, M.; Ciosek, P.; Wróblewski, W. Influence of Experimental Conditions on Electronic Tongue Results—Case of Valsartan Minitablets Dissolution. Sensors 2016, 16, 1353.

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