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Sensors 2016, 16(9), 1354; doi:10.3390/s16091354

Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers

1
Department of Electrical Engineering, Indian Institute of Technology Hyderabad, Hyderabad 502205, India
2
Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Hyderabad 502205, India
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Madou
Received: 31 May 2016 / Revised: 24 July 2016 / Accepted: 28 July 2016 / Published: 23 August 2016
(This article belongs to the Special Issue Carbon MEMS and NEMS for Sensor Applications)
View Full-Text   |   Download PDF [4266 KB, uploaded 23 August 2016]   |  

Abstract

This paper reports the synthesis and fabrication of aligned electrospun nanofibers derived out of multiwalled carbon nanotubes (MWCNTs) embedded SU-8 photoresist, which are targeted towards ultrasensitive biosensor applications. The ultrasensitivity (detection in the range of fg/mL) and the specificity of these biosensors were achieved by complementing the inherent advantages of MWCNTs such as high surface to volume ratio and excellent electrical and transduction properties with the ease of surface functionalization of SU-8. The electrospinning process was optimized to precisely align nanofibers in between two electrodes of a copper microelectrode array. MWCNTs not only enhance the conductivity of SU-8 nanofibers but also act as transduction elements. In this paper, MWCNTs were embedded way beyond the percolation threshold and the optimum percentage loading of MWCNTs for maximizing the conductivity of nanofibers was figured out experimentally. As a proof of concept, the detection of myoglobin, an important biomarker for on-set of Acute Myocardial Infection (AMI) has been demonstrated by functionalizing the nanofibers with anti-myoglobin antibodies and carrying out detection using a chemiresistive method. This simple and robust device yielded a detection limit of 6 fg/mL. View Full-Text
Keywords: ultra sensitivity; nanobiosensors; electrospinning; MWCNTs; SU-8; chemiresistive ultra sensitivity; nanobiosensors; electrospinning; MWCNTs; SU-8; chemiresistive
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Durga Prakash, M.; Vanjari, S.R.K.; Sharma, C.S.; Singh, S.G. Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers. Sensors 2016, 16, 1354.

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