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Sensors 2016, 16(8), 1326; doi:10.3390/s16081326

A Microfluidic Approach for Inducing Cell Rotation by Means of Hydrodynamic Forces

1
Institute for Microelectronics and Microsystems, National Research Council, Naples 80131, Italy
2
Rowland Institute at Harvard, Harvard University, 100 E. Land Blvd., Cambridge, MA 02142, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Fan-Gang Tseng
Received: 12 July 2016 / Revised: 11 August 2016 / Accepted: 12 August 2016 / Published: 19 August 2016
(This article belongs to the Special Issue Biomicrofluidics)
View Full-Text   |   Download PDF [3844 KB, uploaded 19 August 2016]   |  

Abstract

Microfluidic technology allows to realize devices in which cells can be imaged in their three-dimensional shape. However, there are still some limitations in the method, due to the fact that cells follow a straight path while they are flowing in a channel. This can result in a loss in information, since only one side of the cell will be visible. Our work has started from the consideration that if a cell rotates, it is possible to overcome this problem. Several approaches have been proposed for cell manipulation in microfluidics. In our approach, cells are controlled by only taking advantages of hydrodynamic forces. Two different devices have been designed, realized, and tested. The first device induces cell rotation in a plane that is parallel (in-plane) to the observation plane, while the second one induce rotation in a plane perpendicular (out-of-plane) to the observation plane. View Full-Text
Keywords: microfluidics; rotation; hydrodynamic manipulation microfluidics; rotation; hydrodynamic manipulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Torino, S.; Iodice, M.; Rendina, I.; Coppola, G.; Schonbrun, E. A Microfluidic Approach for Inducing Cell Rotation by Means of Hydrodynamic Forces. Sensors 2016, 16, 1326.

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