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Sensors 2016, 16(8), 1231; doi:10.3390/s16081231

A Novel One-Step Fabricated, Droplet-Based Electrochemical Sensor for Facile Biochemical Assays

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
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Author to whom correspondence should be addressed.
Academic Editor: Flavio Maran
Received: 16 April 2016 / Revised: 26 July 2016 / Accepted: 27 July 2016 / Published: 4 August 2016
(This article belongs to the Section Biosensors)
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Abstract

A simple, novel concept for the one-step fabrication of a low-cost, easy-to-use droplet-based electrochemical (EC) sensor is described, in which the EC reagents are contained in a droplet and the droplet assay is operated on a simple planar surface instead of in a complicated closed channel/chamber. In combination with an elegant carbon electrode configuration, screen-printed on a widely available polyethylene terephthalate (PET) substrate, the developed sensor exhibits a stable solution-restriction capacity and acceptable EC response, and thus can be used directly for the detection of different analytes (including ascorbic acid (AA), copper ions (Cu2+), 2′-deoxyguanosine 5′-triphosphate (dGTP) and ferulic acid (FA)), without any pretreatment. The obtained, acceptable linear ranges/detection limits for AA, Cu2+, dGTP and FA are 0.5–10/0.415 mM, (0.0157–0.1574 and 0.1574–1.5736)/0.011 mM, 0.01–0.1/0.008 mM and 0.0257–0.515/0.024 mM, respectively. Finally, the utility of the droplet-based EC sensor was demonstrated for the determination of AA in two commercial beverages, and of Cu2+ in two water samples, with reliable recovery and good stability. The applicability of the droplet-based sensor demonstrates that the proposed EC strategy is potentially a cost-effective solution for a series of biochemical sensing applications in public health, environmental monitoring, and the developing world. View Full-Text
Keywords: one-step fabrication; droplet-based sensor; electrochemical sensing; biochemical assays one-step fabrication; droplet-based sensor; electrochemical sensing; biochemical assays
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yao, Y.; Zhang, C. A Novel One-Step Fabricated, Droplet-Based Electrochemical Sensor for Facile Biochemical Assays. Sensors 2016, 16, 1231.

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