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Sensors 2016, 16(8), 1175; doi:10.3390/s16081175

Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications

Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan
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Author to whom correspondence should be addressed.
Academic Editors: Zhiping Wang and Charles Chun Yang
Received: 31 May 2016 / Revised: 18 July 2016 / Accepted: 21 July 2016 / Published: 27 July 2016
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
View Full-Text   |   Download PDF [2841 KB, uploaded 27 July 2016]   |  

Abstract

Surface plasmon resonance (SPR) is a label-free, highly-sensitive, and real-time sensing technique. Conventional SPR sensors, which involve a planar thin gold film, have been widely exploited in biosensing; various miniaturized formats have been devised for portability purposes. Another type of SPR sensor which utilizes localized SPR (LSPR), is based on metal nanostructures with surface plasmon modes at the structural interface. The resonance condition is sensitive to the refractive index change of the local medium. The principles of these two types of SPR sensors are reviewed and their integration with microfluidic platforms is described. Further applications of microfluidic SPR sensors to point-of-care (POC) diagnostics are discussed. View Full-Text
Keywords: surface plasmon resonance (SPR); microfluidics; immunosensing surface plasmon resonance (SPR); microfluidics; immunosensing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, D.-S.; Fan, S.-K. Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications. Sensors 2016, 16, 1175.

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