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Sensors 2016, 16(6), 880; doi:10.3390/s16060880

Design, Fabrication, Simulation and Characterization of a Novel Dual-Sided Microelectrode Array for Deep Brain Recording and Stimulation

1,2
,
1,2
,
1,2
and
1,2,*
1
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
2
National Engineering Research Center of Health Care and Medical Devices, Xi’an Jiaotong University Branch, Xi’an 710049, China
*
Author to whom correspondence should be addressed.
Academic Editors: Zhiping Wang and Charles Chun Yang
Received: 6 April 2016 / Revised: 6 May 2016 / Accepted: 20 May 2016 / Published: 15 June 2016
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
View Full-Text   |   Download PDF [6799 KB, uploaded 15 June 2016]   |  

Abstract

In this paper, a novel dual-sided microelectrode array is specially designed and fabricated for a rat Parkinson’s disease (PD) model to study the mechanisms of deep brain stimulation (DBS). The fabricated microelectrode array can stimulate the subthalamic nucleus and simultaneously record electrophysiological information from multiple nuclei of the basal ganglia system. The fabricated microelectrode array has a long shaft of 9 mm and each planar surface is equipped with three stimulating sites (diameter of 100 μm), seven electrophysiological recording sites (diameter of 20 μm) and four sites with diameter of 50 μm used for neurotransmitter measurements in future work. The performances of the fabricated microelectrode array were characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry. In addition, the stimulating effects of the fabricated microelectrode were evaluated by finite element modeling (FEM). Preliminary animal experiments demonstrated that the designed microelectrode arrays can record spontaneous discharge signals from the striatum, the subthalamic nucleus and the globus pallidus interna. The designed and fabricated microelectrode arrays provide a powerful research tool for studying the mechanisms of DBS in rat PD models. View Full-Text
Keywords: Parkinson’s disease; mechanisms of deep brain stimulation; dual-sided microelectrode array Parkinson’s disease; mechanisms of deep brain stimulation; dual-sided microelectrode array
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhao, Z.; Gong, R.; Huang, H.; Wang, J. Design, Fabrication, Simulation and Characterization of a Novel Dual-Sided Microelectrode Array for Deep Brain Recording and Stimulation. Sensors 2016, 16, 880.

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