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Sensors 2016, 16(6), 828; doi:10.3390/s16060828

Homogeneous Biosensing Based on Magnetic Particle Labels

1
Molecular Diagnostics, AIT Austrian Institute of Technology, Vienna1220, Austria
2
Fachbereich Physik, Philipps-Universität Marburg, Marburg 35037, Germany
3
Laboratoire de Physique et Chimie des Nano-objets (LPCNO), Université de Toulouse, INSA, UPS, CNRS, Toulouse 31077, France
4
Institute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, Braunschweig 38106, Germany
5
Experimentalphysik, Universität des Saarlandes, Saarbrücken 66123, Germany
NABLA Lab, Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University for Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
Diagnostic and Interventional Radiology Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Hütten
Received: 22 April 2016 / Revised: 30 May 2016 / Accepted: 1 June 2016 / Published: 6 June 2016
(This article belongs to the Special Issue Magnetic Sensor Device-Part 1)

Abstract

The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation. View Full-Text
Keywords: biosensor; magnetic nanoparticle; homogeneous assay; magnetorelaxation; AC susceptibility; NMR; magnetic relaxation switch; asynchronous magnetorotation; magneto-optics; nanorod biosensor; magnetic nanoparticle; homogeneous assay; magnetorelaxation; AC susceptibility; NMR; magnetic relaxation switch; asynchronous magnetorotation; magneto-optics; nanorod
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Schrittwieser, S.; Pelaz, B.; Parak, W.J.; Lentijo-Mozo, S.; Soulantica, K.; Dieckhoff, J.; Ludwig, F.; Guenther, A.; Tschöpe, A.; Schotter, J. Homogeneous Biosensing Based on Magnetic Particle Labels. Sensors 2016, 16, 828.

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