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Sensors 2016, 16(6), 778; doi:10.3390/s16060778

Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept

Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada
Department of Chemistry, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada
Ophthalmology Department, Faculty of Medecine, Université Laval, Québec City, QC G1V 0A6, Canada
Research Center of CHU de Quebec, (Centre Hospitalier Universitaire)-Université Laval, Québec City, QC G1V 0A6, Canada
Centre de Recherche du Centre Hospitalier Universitaire de Québec (CR-CHUQ), Axe Médecine Régénératrice, Québec City, QC G1L 3L5, Canada
Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Québec City, QC G1V 0A6, Canada
Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, Québec City, QC G1V 0A6, Canada
These authors contributed equally to this work.
Current address: Laval University; Adrien-Pouliot Build. Room 2110; Department of Electrical and Computer Engineering, 1065, Médecine Av., Québec, QC G1V 0A6, Canada.
Author to whom correspondence should be addressed.
Academic Editor: Vittorio M. N. Passaro
Received: 21 April 2016 / Revised: 13 May 2016 / Accepted: 23 May 2016 / Published: 28 May 2016
(This article belongs to the Special Issue Microfluidics-Based Microsystem Integration Research)
View Full-Text   |   Download PDF [9392 KB, uploaded 28 May 2016]   |  


In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an “intelligent” drug delivery system based on a feedback loop to monitor drug delivery. View Full-Text
Keywords: lab-on-chip; modular microfluidics; system integration lab-on-chip; modular microfluidics; system integration

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kara, A.; Rouillard, C.; Mathault, J.; Boisvert, M.; Tessier, F.; Landari, H.; Melki, I.; Laprise-Pelletier, M.; Boisselier, E.; Fortin, M.-A.; Boilard, E.; Greener, J.; Miled, A. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept. Sensors 2016, 16, 778.

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