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Sensors 2016, 16(4), 476; doi:10.3390/s16040476

Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications

Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USA
Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA
WiseWear Corporation, New York, NY 10018, USA
College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
Author to whom correspondence should be addressed.
Received: 18 January 2016 / Revised: 28 March 2016 / Accepted: 30 March 2016 / Published: 4 April 2016
(This article belongs to the Special Issue Infrared and THz Sensing and Imaging)
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THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 °C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells. View Full-Text
Keywords: cell trapping; lab-on-a-chip; microfluidics; THz spectroscopy cell trapping; lab-on-a-chip; microfluidics; THz spectroscopy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tang, Q.; Liang, M.; Lu, Y.; Wong, P.K.; Wilmink, G.J.; Zhang, D.D.; Xin, H. Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications. Sensors 2016, 16, 476.

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