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Sensors 2016, 16(12), 2058; doi:10.3390/s16122058

Real-Time Analysis of Isoprene in Breath by Using Ultraviolet-Absorption Spectroscopy with a Hollow Optical Fiber Gas Cell

1
Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan
2
Graduate School of Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Vittorio M. N. Passaro
Received: 21 November 2016 / Revised: 28 November 2016 / Accepted: 30 November 2016 / Published: 5 December 2016
(This article belongs to the Section Physical Sensors)
View Full-Text   |   Download PDF [9061 KB, uploaded 5 December 2016]   |  

Abstract

A breath analysis system based on ultraviolet-absorption spectroscopy was developed by using a hollow optical fiber as a gas cell for real-time monitoring of isoprene in breath. The hollow optical fiber functions as an ultra-small-volume gas cell with a long path. The measurement sensitivity of the system was evaluated by using nitric-oxide gas as a gas sample. The evaluation result showed that the developed system, using a laser-driven, high-intensity light source and a 3-m-long, aluminum-coated hollow optical fiber, could successfully measure nitric-oxide gas with a 50 ppb concentration. An absorption spectrum of a breath sample in the wavelength region of around 200–300 nm was measured, and the measured spectrum revealed the main absorbing components in breath as water vapor, isoprene, and ozone converted from oxygen by radiation of ultraviolet light. The concentration of isoprene in breath was estimated by multiple linear regression. The regression analysis results showed that the proposed analysis system enables real-time monitoring of isoprene during the exhaling of breath. Accordingly, it is suitable for measuring the circadian variation of isoprene. View Full-Text
Keywords: breath analysis; isoprene; ultraviolet spectroscopy; hollow-optical fiber breath analysis; isoprene; ultraviolet spectroscopy; hollow-optical fiber
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Iwata, T.; Katagiri, T.; Matsuura, Y. Real-Time Analysis of Isoprene in Breath by Using Ultraviolet-Absorption Spectroscopy with a Hollow Optical Fiber Gas Cell. Sensors 2016, 16, 2058.

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