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Sensors 2016, 16(12), 2035; doi:10.3390/s16122035

Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate

ISRC/ASRI, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Human Care System Research Center, Convergence System R&D Division, Korea Electronics Technology Institute, 25 Saenari-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13509, Korea
Department of Physiology, College of Medicine, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk 28644, Korea
Author to whom correspondence should be addressed.
Academic Editors: Dragan Indjin, Željka Cvejić and Małgorzata Jędrzejewska-Szczerska
Received: 7 September 2016 / Revised: 7 November 2016 / Accepted: 25 November 2016 / Published: 1 December 2016
View Full-Text   |   Download PDF [9434 KB, uploaded 1 December 2016]   |  


This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transistors; it has the functions of detecting light, generating a stimulation signal in proportion to the light intensity, and transmitting the signal to a micro electrode. To show the applicability of the proposed neural stimulation device as a high-resolution retinal prosthesis system, a high-density neural stimulation device with a unit cell size of 110 × 110 μ m and a resolution of 32 × 32 was fabricated on a flexible film with a thickness of approximately 50 μm. Its effectiveness as a retinal stimulation device was then evaluated using a unit cell in an in vitro animal experiment involving the retinal tissue of retinal Degeneration 1 (rd1) mice. Experiments wherein stimulation pulses were applied to the retinal tissues successfully demonstrate that the number of spikes in neural response signals increases in proportion to light intensity. View Full-Text
Keywords: neuron stimulation; silicon nanowire; photodetector; micro electrode; retinal prosthesis neuron stimulation; silicon nanowire; photodetector; micro electrode; retinal prosthesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jung, S.W.; Shin, J.Y.; Pi, K.; Goo, Y.S.; Cho, D.-I.“. Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate. Sensors 2016, 16, 2035.

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