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Sensors 2016, 16(12), 2035; doi:10.3390/s16122035

Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate

1
ISRC/ASRI, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
2
Human Care System Research Center, Convergence System R&D Division, Korea Electronics Technology Institute, 25 Saenari-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13509, Korea
3
Department of Physiology, College of Medicine, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk 28644, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Dragan Indjin, Željka Cvejić and Małgorzata Jędrzejewska-Szczerska
Received: 7 September 2016 / Revised: 7 November 2016 / Accepted: 25 November 2016 / Published: 1 December 2016
View Full-Text   |   Download PDF [9434 KB, uploaded 1 December 2016]   |  

Abstract

This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transistors; it has the functions of detecting light, generating a stimulation signal in proportion to the light intensity, and transmitting the signal to a micro electrode. To show the applicability of the proposed neural stimulation device as a high-resolution retinal prosthesis system, a high-density neural stimulation device with a unit cell size of 110 × 110 μ m and a resolution of 32 × 32 was fabricated on a flexible film with a thickness of approximately 50 μm. Its effectiveness as a retinal stimulation device was then evaluated using a unit cell in an in vitro animal experiment involving the retinal tissue of retinal Degeneration 1 (rd1) mice. Experiments wherein stimulation pulses were applied to the retinal tissues successfully demonstrate that the number of spikes in neural response signals increases in proportion to light intensity. View Full-Text
Keywords: neuron stimulation; silicon nanowire; photodetector; micro electrode; retinal prosthesis neuron stimulation; silicon nanowire; photodetector; micro electrode; retinal prosthesis
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MDPI and ACS Style

Jung, S.W.; Shin, J.Y.; Pi, K.; Goo, Y.S.; Cho, D.-I.“. Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate. Sensors 2016, 16, 2035.

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