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Sensors 2016, 16(11), 1891; doi:10.3390/s16111891

Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns

1
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan
2
Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
3
Figaro Engineering Inc., 1-5-11 Sembanishi, Minoh, Osaka 562-8505, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Received: 27 July 2016 / Revised: 2 November 2016 / Accepted: 3 November 2016 / Published: 10 November 2016
(This article belongs to the Special Issue Gas Sensors for Health Care and Medical Applications)
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Abstract

Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls). The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis. View Full-Text
Keywords: lung cancer; volatile organic compounds; exhaled breath analysis; gas condenser-equipped gas chromatography-mass spectrometry; condenser; GC; sensor-type prototype system lung cancer; volatile organic compounds; exhaled breath analysis; gas condenser-equipped gas chromatography-mass spectrometry; condenser; GC; sensor-type prototype system
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Itoh, T.; Miwa, T.; Tsuruta, A.; Akamatsu, T.; Izu, N.; Shin, W.; Park, J.; Hida, T.; Eda, T.; Setoguchi, Y. Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns. Sensors 2016, 16, 1891.

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