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Sensors 2016, 16(11), 1871; doi:10.3390/s16111871

A Portable Smart-Phone Readout Device for the Detection of Mercury Contamination Based on an Aptamer-Assay Nanosensor

1
Department of Bioengineering, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou 510632, China
2
Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China
3
Institute of Biotranslational Medicine, Jinan University, Guangzhou 510632, China
*
Author to whom correspondence should be addressed.
Academic Editor: Meyya Meyyappan
Received: 11 October 2016 / Revised: 30 October 2016 / Accepted: 2 November 2016 / Published: 8 November 2016
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [4623 KB, uploaded 8 November 2016]   |  

Abstract

The detection of environmental mercury (Hg) contamination requires complex and expensive instruments and professional technicians. We present a simple, sensitive, and portable Hg2+ detection system based on a smartphone and colorimetric aptamer nanosensor. A smartphone equipped with a light meter app was used to detect, record, and process signals from a smartphone-based microwell reader (MR S-phone), which is composed of a simple light source and a miniaturized assay platform. The colorimetric readout of the aptamer nanosensor is based on a specific interaction between the selected aptamer and Hg2+, which leads to a color change in the reaction solution due to an aggregation of gold nanoparticles (AuNPs). The MR S-phone-based AuNPs-aptamer colorimetric sensor system could reliably detect Hg2+ in both tap water and Pearl River water samples and produced a linear colorimetric readout of Hg2+ concentration in the range of 1 ng/mL–32 ng/mL with a correlation of 0.991, and a limit of detection (LOD) of 0.28 ng/mL for Hg2+. The detection could be quickly completed in only 20 min. Our novel mercury detection assay is simple, rapid, and sensitive, and it provides new strategies for the on-site detection of mercury contamination in any environment. View Full-Text
Keywords: smartphone; microwell reader; mercury ions; colorimetric aptamer nanosensor; gold nanoparticle smartphone; microwell reader; mercury ions; colorimetric aptamer nanosensor; gold nanoparticle
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Xiao, W.; Xiao, M.; Fu, Q.; Yu, S.; Shen, H.; Bian, H.; Tang, Y. A Portable Smart-Phone Readout Device for the Detection of Mercury Contamination Based on an Aptamer-Assay Nanosensor. Sensors 2016, 16, 1871.

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