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Sensors 2015, 15(9), 21239-21264; doi:10.3390/s150921239

Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing

1
UPMC Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, 4 Place Jussieu, F-75005 Paris, France
2
CNRS, UMR 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France
3
Center for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore
4
Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS, (UMR 7244), 74 rue Marcel Cachin, F-93017 Bobigny, France
5
AIT Austrian Institute of Technology, Donau City Strasse 1, A-1220 Vienna, Austria
*
Author to whom correspondence should be addressed.
Academic Editors: M. Selim Ünlü and Ayca Yalcin Ozkumur
Received: 15 March 2015 / Revised: 6 August 2015 / Accepted: 10 August 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
View Full-Text   |   Download PDF [2621 KB, uploaded 28 August 2015]   |  

Abstract

In this short summary we summarize some of the latest developments in vibrational spectroscopic tools applied for the sensing of (small) molecules and biomolecules in a label-free mode of operation. We first introduce various concepts for the enhancement of InfraRed spectroscopic techniques, including the principles of Attenuated Total Reflection InfraRed (ATR-IR), (phase-modulated) InfraRed Reflection Absorption Spectroscopy (IRRAS/PM-IRRAS), and Surface Enhanced Infrared Reflection Absorption Spectroscopy (SEIRAS). Particular attention is put on the use of novel nanostructured substrates that allow for the excitation of propagating and localized surface plasmon modes aimed at operating additional enhancement mechanisms. This is then be complemented by the description of the latest development in Surface- and Tip-Enhanced Raman Spectroscopies, again with an emphasis on the detection of small molecules or bioanalytes. View Full-Text
Keywords: biosensors; infrared; plasmonic; enhanced spectroscopies; SERS; IRRAS biosensors; infrared; plasmonic; enhanced spectroscopies; SERS; IRRAS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Boujday, S.; Chapelle, M.L.; Srajer, J.; Knoll, W. Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing. Sensors 2015, 15, 21239-21264.

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