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Sensors 2015, 15(7), 17649-17665; doi:10.3390/s150717649

Interferometric Reflectance Imaging Sensor (IRIS)—A Platform Technology for Multiplexed Diagnostics and Digital Detection

1
Department of Electrical and Computer Engineering, Boston University, 8 St. Mary's Street, Boston, MA 02215, USA
2
Department of Biomedical Engineering, Boston University, 8 St. Mary's Street, Boston, MA 02215, USA
3
Department of Electrical and Electronics Engineering and School of Medicine, Bahcesehir University, Ciragan Caddesi, No:4-6, Besiktas, Istanbul 34353, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 8 April 2015 / Revised: 30 June 2015 / Accepted: 14 July 2015 / Published: 20 July 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
View Full-Text   |   Download PDF [3300 KB, uploaded 23 July 2015]   |  

Abstract

Over the last decade, the growing need in disease diagnostics has stimulated rapid development of new technologies with unprecedented capabilities. Recent emerging infectious diseases and epidemics have revealed the shortcomings of existing diagnostics tools, and the necessity for further improvements. Optical biosensors can lay the foundations for future generation diagnostics by providing means to detect biomarkers in a highly sensitive, specific, quantitative and multiplexed fashion. Here, we review an optical sensing technology, Interferometric Reflectance Imaging Sensor (IRIS), and the relevant features of this multifunctional platform for quantitative, label-free and dynamic detection. We discuss two distinct modalities for IRIS: (i) low-magnification (ensemble biomolecular mass measurements) and (ii) high-magnification (digital detection of individual nanoparticles) along with their applications, including label-free detection of multiplexed protein chips, measurement of single nucleotide polymorphism, quantification of transcription factor DNA binding, and high sensitivity digital sensing and characterization of nanoparticles and viruses. View Full-Text
Keywords: optical biosensor; interferometry; label-free; digital detection; nanoparticle; virus; single nucleotide polymorphism optical biosensor; interferometry; label-free; digital detection; nanoparticle; virus; single nucleotide polymorphism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Avci, O.; Ünlü, N.L.; Özkumur, A.Y.; Ünlü, M.S. Interferometric Reflectance Imaging Sensor (IRIS)—A Platform Technology for Multiplexed Diagnostics and Digital Detection. Sensors 2015, 15, 17649-17665.

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