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Sensors 2015, 15(8), 20648-20658; doi:10.3390/s150820648

Highly Sensitive Electrochemical Determination of Alfatoxin B1 Using Quantum Dots-Assembled Amplification Labels

1
Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang, Ningbo University, Ningbo 315211, China
2
Food Science & Nutrition Department, Nanjing Normal University, Nanjing 210097, China
3
School of Electronic Engineering, Xidian University, Xi'an 710071, China
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 24 June 2015 / Revised: 6 August 2015 / Accepted: 17 August 2015 / Published: 20 August 2015
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [1137 KB, uploaded 20 August 2015]   |  

Abstract

A competitive electrochemical immunoassay for highly sensitive detection of AFB1 is demonstrated using layer-by-layer (LBL) assembled quantum dots (QDs) as labels. To investigate the effects of the higher sensitivity of square wave voltammetric stripping (SWV) and of the LBL technique on the proposed immunoassays, the proposed assay was compared to electrochemical (EC) and fluorescent immunoassays, which did not use LBL technology. Peanut samples were analyzed using the three immunoassays. The limits of detection (LODs) were 0.018, 0.046 and 0.212 ng/mL, respectively, while the sensitivities were 0.308, 1.011 and 4.594 ng/mL, respectively. The proposed electrochemical immunoassay displayed a significant improvement in sensitivity, thereby providing a simple and sensitive alternative strategy for determining AFB1 levels in peanut samples. View Full-Text
Keywords: quantum dots; layer-by-layer assembly; electrochemical immunoassay; AFB1 detection quantum dots; layer-by-layer assembly; electrochemical immunoassay; AFB1 detection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zeng, X.; Gao, H.; Pan, D.; Sun, Y.; Cao, J.; Wu, Z.; Pan, Z. Highly Sensitive Electrochemical Determination of Alfatoxin B1 Using Quantum Dots-Assembled Amplification Labels. Sensors 2015, 15, 20648-20658.

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