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Sensors 2015, 15(12), 31973-31986; doi:10.3390/s151229900

Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM

1
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
2
Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
3
Graduate School of Informatics, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan
4
Advanced Biomedical Engineering Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
5
Division of Multidisciplinary Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan
Present Address: Department of Life System, Institute of Technology and Science, Graduate School, Tokushima University, Tokushima 770-8506, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 2 November 2015 / Revised: 8 December 2015 / Accepted: 11 December 2015 / Published: 18 December 2015
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [2857 KB, uploaded 18 December 2015]   |  

Abstract

Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo. View Full-Text
Keywords: chiral dendrimer; gadolinium; contrast agent; magnetic resonance imaging (MRI); quartz crystal microbalance (QCM); association constant (Ka) chiral dendrimer; gadolinium; contrast agent; magnetic resonance imaging (MRI); quartz crystal microbalance (QCM); association constant (Ka)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Miyake, Y.; Ishikawa, S.; Kimura, Y.; Son, A.; Imai, H.; Matsuda, T.; Yamada, H.; Toshimitsu, A.; Kondo, T. Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM. Sensors 2015, 15, 31973-31986.

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