Next Article in Journal
Corrosion Resistant FBG-Based Quasi-Distributed Sensor for Crude Oil Tank Dynamic Temperature Profile Monitoring
Previous Article in Journal
A Review of Intelligent Driving Style Analysis Systems and Related Artificial Intelligence Algorithms
Article Menu

Export Article

Open AccessArticle
Sensors 2015, 15(12), 30683-30692; doi:10.3390/s151229823

Evaluation of Chemical Interactions between Small Molecules in the Gas Phase Using Chemical Force Microscopy

1
Center for Biomicrosystems, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Korea
2
Department of Chemical and Biological Engineering, Korea University, 5-ga Annam-dong, Seongbuk-gu, Seoul 136-713, Korea
3
Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology(KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Korea
4
Department of Applied Chemistry, Hanyang University, Sangnok-gu, Ansan, Gyeonggi-do 15588, Korea
5
Center for Sensor System Research, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Received: 2 November 2015 / Revised: 2 December 2015 / Accepted: 2 December 2015 / Published: 4 December 2015
(This article belongs to the Section Chemical Sensors)
View Full-Text   |   Download PDF [1909 KB, uploaded 4 December 2015]   |  

Abstract

Chemical force microscopy analyzes the interactions between various chemical/biochemical moieties in situ. In this work we examined force-distance curves and lateral force to measure the interaction between modified AFM tips and differently functionalized molecular monolayers. Especially for the measurements in gas phase, we investigated the effect of humidity on the analysis of force-distance curves and the images in lateral force mode. Flat chemical patterns composed of different functional groups were made through micro-contact printing and lateral force mode provided more resolved analysis of the chemical patterns. From the images of 1-octadecanethiol/11-mercapto-1-undecanoic acid patterns, the amine group functionalized tip brought out higher contrast of the patterns than an intact silicon nitride tip owing to the additional chemical interaction between carboxyl and amine groups. For more complex chemical interactions, relative chemical affinities toward specific peptides were assessed on the pattern of 1-octadecanethiol/phenyl-terminated alkanethiol. The lateral image of chemical force microscopy reflected specific preference of a peptide to phenyl group as well as the hydrophobic interaction. View Full-Text
Keywords: chemical force microscopy; micro-contact printing; lateral force image; benzene specific peptide chemical force microscopy; micro-contact printing; lateral force image; benzene specific peptide
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, J.; Ju, S.; Kim, I.T.; Jung, S.-H.; Min, S.-J.; Kim, C.; Sim, S.J.; Kim, S.K. Evaluation of Chemical Interactions between Small Molecules in the Gas Phase Using Chemical Force Microscopy. Sensors 2015, 15, 30683-30692.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top