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Sensors 2015, 15(1), 1389-1403; doi:10.3390/s150101389

Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors

1
Chemistry Department, Faculty of Art and Science, Pamukkale University, 20070 Denizli, Turkey
2
Biochemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey
3
Institute on Drug Abuse, Toxicology and Pharmaceutical Science (BATI), Ege University, 35100 Bornova, Izmir, Turkey
*
Authors to whom correspondence should be addressed.
Received: 28 November 2014 / Accepted: 4 January 2015 / Published: 13 January 2015
(This article belongs to the Special Issue Amperometric Biosensors)
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Abstract

Herein, we report a novel ferrocenyldithiophosphonate functional conducting polymer and its use as an immobilization matrix in amperometric biosensor applications. Initially, 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)amidoferrocenyldithiophosphonate was synthesized and copolymerized with 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzenamine at graphite electrodes. The amino groups on the polymer were utilized for covalent attachment of the enzyme glucose oxidase. Besides, ferrocene on the backbone was used as a redox mediator during the electrochemical measurements. Prior to the analytical characterization, optimization studies were carried out. The changes in current signals at +0.45 V were proportional to glucose concentration from 0.5 to 5.0 mM. Finally, the resulting biosensor was applied for glucose analysis in real samples and the data were compared with the spectrophotometric Trinder method. View Full-Text
Keywords: ferrocenyldithiophosphonate; conducting polymers; biosensor; glucose ferrocenyldithiophosphonate; conducting polymers; biosensor; glucose
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ayranci, R.; Demirkol, D.O.; Ak, M.; Timur, S. Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors. Sensors 2015, 15, 1389-1403.

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