Next Article in Journal
Physico-Mathematical Simulation of a Homogeneous Thermal Field of Multichannel Raster Matrixes for Sensors of Oxygen
Next Article in Special Issue
A Chronoamperometric Screen Printed Carbon Biosensor Based on Alkaline Phosphatase Inhibition for W(VI) Determination in Water, Using 2-Phospho-l-Ascorbic Acid Trisodium Salt as a Substrate
Previous Article in Journal
Cooperative Surveillance and Pursuit Using Unmanned Aerial Vehicles and Unattended Ground Sensors
Previous Article in Special Issue
Combining Electrochemical Sensors with Miniaturized Sample Preparation for Rapid Detection in Clinical Samples
Article Menu

Export Article

Open AccessArticle
Sensors 2015, 15(1), 1389-1403; doi:10.3390/s150101389

Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors

Chemistry Department, Faculty of Art and Science, Pamukkale University, 20070 Denizli, Turkey
Biochemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey
Institute on Drug Abuse, Toxicology and Pharmaceutical Science (BATI), Ege University, 35100 Bornova, Izmir, Turkey
Authors to whom correspondence should be addressed.
Received: 28 November 2014 / Accepted: 4 January 2015 / Published: 13 January 2015
(This article belongs to the Special Issue Amperometric Biosensors)
View Full-Text   |   Download PDF [1252 KB, uploaded 13 January 2015]   |  


Herein, we report a novel ferrocenyldithiophosphonate functional conducting polymer and its use as an immobilization matrix in amperometric biosensor applications. Initially, 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)amidoferrocenyldithiophosphonate was synthesized and copolymerized with 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzenamine at graphite electrodes. The amino groups on the polymer were utilized for covalent attachment of the enzyme glucose oxidase. Besides, ferrocene on the backbone was used as a redox mediator during the electrochemical measurements. Prior to the analytical characterization, optimization studies were carried out. The changes in current signals at +0.45 V were proportional to glucose concentration from 0.5 to 5.0 mM. Finally, the resulting biosensor was applied for glucose analysis in real samples and the data were compared with the spectrophotometric Trinder method. View Full-Text
Keywords: ferrocenyldithiophosphonate; conducting polymers; biosensor; glucose ferrocenyldithiophosphonate; conducting polymers; biosensor; glucose

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ayranci, R.; Demirkol, D.O.; Ak, M.; Timur, S. Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors. Sensors 2015, 15, 1389-1403.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top