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Sensors 2014, 14(10), 19275-19306; doi:10.3390/s141019275

Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics

1
Department of Electronics, Bioelectronics and Nanobioengineering Research Group (SIC-BIO), University of Barcelona, Martí i Franquès 1, Barcelona 08028, Spain
2
Department of Public Economy, Political Economy and Spanish Economy, University of Barcelona, Av. Diagonal 690-696, Barcelona 08034, Spain
3
CREB-Biomedical Engineering Research Centre, Technical University of Catalonia, Pau Gargallo 5, Barcelona 08028, Spain
4
IBEC-Institute for Bioengineering of Catalonia, Nanobioengineering Research Group, Baldiri Reixac 10-12, Barcelona 08028, Spain
5
CIBER-BBN-Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, María de Luna 11, Edificio CEEI, Zaragoza 50018, Spain
*
Author to whom correspondence should be addressed.
Received: 13 June 2014 / Revised: 19 September 2014 / Accepted: 24 September 2014 / Published: 16 October 2014
(This article belongs to the Special Issue Implantable Sensors)
View Full-Text   |   Download PDF [2408 KB, uploaded 16 October 2014]   |  

Abstract

The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs) could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device. View Full-Text
Keywords: implantable multi-sensor; biosensor; biotelemetry; biocompatible; KET; nanomedicine; personalized medicine; innovation implantable multi-sensor; biosensor; biotelemetry; biocompatible; KET; nanomedicine; personalized medicine; innovation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Juanola-Feliu, E.; Miribel-Català, P.L.; Avilés, C.P.; Colomer-Farrarons, J.; González-Piñero, M.; Samitier, J. Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics. Sensors 2014, 14, 19275-19306.

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