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Sensors 2014, 14(1), 458-467; doi:10.3390/s140100458

Mycobacterium tuberculosis DNA Detection Using Surface Plasmon Resonance Modulated by Telecommunication Wavelength

1
Department of Electronic Engineering, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Rd., Taipei 10607, Taiwan
2
Department of Medical Research, Mackay Memorial Hospital, Taipei 25160, Taiwan
3
Division of Chest Medicine, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
4
Department of Medicine, Mackay Medical College, 25245, New Taipei City, Taiwan
5
Department of Laboratory Medicine, Mackay Memorial Hospital, Taipei 25160, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 October 2013 / Revised: 18 December 2013 / Accepted: 20 December 2013 / Published: 27 December 2013
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [214 KB, uploaded 21 June 2014]   |  

Abstract

A surface plasmon resonance sensor for Mycobacterium tuberculosis (MTB) deoxyribonucleic acid (DNA) is developed using repeatable telecommunication wavelength modulation based on optical fiber communications laser wavelength and stability. MTB DNA concentrations of 1 μg/mL and 10 μg/mL were successfully demonstrated to have the same spectral half-width in the dip for optimum coupling. The sensitivity was shown to be −0.087 dB/(μg/mL) at all applied telecommunication wavelengths and the highest sensitivity achieved was 115 ng/mL without thiolated DNA immobilization onto a gold plate, which is better than the sensor limit of 400 ng/mL possible with commercial biosensor equipment. View Full-Text
Keywords: Mycobacterium tuberculosis; surface plasmon resonance; wavelength modulation Mycobacterium tuberculosis; surface plasmon resonance; wavelength modulation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hsu, S.-H.; Lin, Y.-Y.; Lu, S.-H.; Tsai, I.-F.; Lu, Y.-T.; Ho, H.-T. Mycobacterium tuberculosis DNA Detection Using Surface Plasmon Resonance Modulated by Telecommunication Wavelength. Sensors 2014, 14, 458-467.

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