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Sensors 2014, 14(1), 458-467; doi:10.3390/s140100458
Article

Mycobacterium tuberculosis DNA Detection Using Surface Plasmon Resonance Modulated by Telecommunication Wavelength

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Received: 28 October 2013 / Revised: 18 December 2013 / Accepted: 20 December 2013 / Published: 27 December 2013
(This article belongs to the Section Biosensors)
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Abstract

A surface plasmon resonance sensor for Mycobacterium tuberculosis (MTB) deoxyribonucleic acid (DNA) is developed using repeatable telecommunication wavelength modulation based on optical fiber communications laser wavelength and stability. MTB DNA concentrations of 1 μg/mL and 10 μg/mL were successfully demonstrated to have the same spectral half-width in the dip for optimum coupling. The sensitivity was shown to be −0.087 dB/(μg/mL) at all applied telecommunication wavelengths and the highest sensitivity achieved was 115 ng/mL without thiolated DNA immobilization onto a gold plate, which is better than the sensor limit of 400 ng/mL possible with commercial biosensor equipment.
Keywords: Mycobacterium tuberculosis; surface plasmon resonance; wavelength modulation Mycobacterium tuberculosis; surface plasmon resonance; wavelength modulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hsu, S.-H.; Lin, Y.-Y.; Lu, S.-H.; Tsai, I.-F.; Lu, Y.-T.; Ho, H.-T. Mycobacterium tuberculosis DNA Detection Using Surface Plasmon Resonance Modulated by Telecommunication Wavelength. Sensors 2014, 14, 458-467.

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