Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine
AbstractWe describe a chemical sensor based on a simple synthesis of zinc oxide nanorods (ZNRs) for the detection of dopamine molecules by a potentiometric approach. The polar nature of dopamine leads to a change of surface charges on the ZNR surface via metal ligand bond formation which results in a measurable electrical signal. ZNRs were grown on a gold-coated glass substrate by a low temperature aqueous chemical growth (ACG) method. Polymeric membranes incorporating β-cyclodextrin (β-CD) and potassium tetrakis (4-chlorophenyl) borate was immobilized on the ZNR surface. The fabricated electrodes were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. The grown ZNRs were well aligned and exhibited good crystal quality. The present sensor system displays a stable potential response for the detection of dopamine in 10−2 mol·L−1 acetic acid/sodium acetate buffer solution at pH 5.45 within a wide concentration range of 1 × 10−6 M–1 × 10−1 M, with sensitivity of 49 mV/decade. The electrode shows a good response time (less than 10 s) and excellent repeatability. This finding can contribute to routine analysis in laboratories studying the neuropharmacology of catecholamines. Moreover, the metal-ligand bonds can be further exploited to detect DA receptors, and for bio-imaging applications.
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Elhag, S.; Ibupoto, Z.H.; Nur, O.; Willander, M. Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine. Sensors 2014, 14, 1654-1664.
Elhag S, Ibupoto ZH, Nur O, Willander M. Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine. Sensors. 2014; 14(1):1654-1664.Chicago/Turabian Style
Elhag, Sami; Ibupoto, Zafar H.; Nur, Omer; Willander, Magnus. 2014. "Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine." Sensors 14, no. 1: 1654-1664.