Sensors 2013, 13(6), 7296-7307; doi:10.3390/s130607296
Article

Simultaneous/Selective Detection of Dopamine and Ascorbic Acid at Synthetic Zeolite-Modified/Graphite-Epoxy Composite Macro/Quasi-Microelectrodes

1 Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, Victoriei Sqr., No. 2, Timisoara 300006, Romania 2 Department of Clinical and Experimental Medicine, University of Sassari, Viale. San Pietro 43/b, Sassari 07100, Italy
* Author to whom correspondence should be addressed.
Received: 10 March 2013; in revised form: 15 April 2013 / Accepted: 2 May 2013 / Published: 3 June 2013
(This article belongs to the Section Chemical Sensors)
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Abstract: The present paper aims to miniaturize a graphite-epoxy and synthetic zeolite-modified graphite-epoxy composite macroelectrode as a quasi-microelectrode aiming in vitro and also, envisaging in vivo simultaneous electrochemical detection of dopamine (DA) and ascorbic acid (AA) neurotransmitters, or DA detection in the presence of AA. The electrochemical behavior and the response of the designed materials to the presence of dopamine and ascorbic acid without any protective membranes were studied by cyclic voltammetry and constant-potential amperometry techniques. The catalytic effect towards dopamine detection was proved for the synthetic zeolite-modified graphite-epoxy composite quasi-microelectrode, allowing increasing the sensitivity and selectivity for this analyte detection, besides a possible electrostatic attraction between dopamine cation and the negative surface of the synthetic zeolite and electrostatic repulsion with ascorbic acid anion. Also, the synthetic zeolite-modified graphite-epoxy composite quasi-microelectrode gave the best electroanalytical parameters for dopamine detection using constant-potential amperometry, the most useful technique for practical applications.
Keywords: dopamine; ascorbic acid; voltammetric detection; amperometric detection; synthetic zeolite-modified graphite-epoxy composite; macroelectrode; quasi-microelectrode

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MDPI and ACS Style

Ilinoiu, E.C.; Manea, F.; Serra, P.A.; Pode, R. Simultaneous/Selective Detection of Dopamine and Ascorbic Acid at Synthetic Zeolite-Modified/Graphite-Epoxy Composite Macro/Quasi-Microelectrodes. Sensors 2013, 13, 7296-7307.

AMA Style

Ilinoiu EC, Manea F, Serra PA, Pode R. Simultaneous/Selective Detection of Dopamine and Ascorbic Acid at Synthetic Zeolite-Modified/Graphite-Epoxy Composite Macro/Quasi-Microelectrodes. Sensors. 2013; 13(6):7296-7307.

Chicago/Turabian Style

Ilinoiu, Elida C.; Manea, Florica; Serra, Pier A.; Pode, Rodica. 2013. "Simultaneous/Selective Detection of Dopamine and Ascorbic Acid at Synthetic Zeolite-Modified/Graphite-Epoxy Composite Macro/Quasi-Microelectrodes." Sensors 13, no. 6: 7296-7307.

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